تفاعل #93058

معادلة التفاعل

isobutyl chloroformate

1-benzyloxycarbonylaminocyclohexane-1-carboxylic acid

triethylamine

L-leucyl-glycinamide

→

1-benzyloxycarbonylaminocyclohex-1-yl-carbonyl-L-leucyl-glycinamide

المردود 59.0%

المذيبات

tetrahydrofuran

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred for 1 hour at -10° C.
2. 2
   أخرىafter which it was evaporated down under reduced pressure
3. 3
   غسيلthe solution was washed successively with 10% strength aqueous citric acid solution, sodium carbonate solution and water
4. 4
   تجفيفdried over sodium sulfate
5. 5
   أخرىevaporated down under reduced pressure

الإجراء التجريبي

4 ml of isobutyl chloroformate were added dropwise to 7.9 g of 1-benzyloxycarbonylaminocyclohexane-1-carboxylic acid and 4 ml of triethylamine in 75 ml of tetrahydrofuran at -10° C., while stirring, 5.6 g of L-leucyl-glycinamide in 50 ml of dimethylformamide were added to the resulting solution of the asymmetric acid anhydride after 15 minutes, and the mixture was stirred for 1 hour at -10° C. and then for 16 hours at room temperature, after which it was evaporated down under reduced pressure. The residue was taken up in ethyl acetate and the solution was washed successively with 10% strength aqueous citric acid solution, sodium carbonate solution and water, dried over sodium sulfate and evaporated down under reduced pressure. 7.5 g of 1-benzyloxycarbonylaminocyclohex-1-yl-carbonyl-L-leucyl-glycinamide were obtained.

المصدر