تفاعل #92862

معادلة التفاعل

methyl 2-bromopropionate

sodium

p-benzyloxyphenol

ether

→

methyl 2-(4-benzyloxyphenoxy)propanoate

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooled reaction mixture
2. 2
   أخرىwas crystallized from methanol

الإجراء التجريبي

A 42 g (0.25 mole) portion of methyl 2-bromopropionate was added to 0.25 mole of the sodium salt of p-benzyloxyphenol (prepared from 13.5 g sodium methoxide and 50 g p-benzyloxyphenoxy) in 70 cc of DMF. The reaction mixture was heated at approximately 80° C. for 14.5 hours. The cooled reaction mixture was then poured into 1 liter ice-water. The product was isolated by ether extraction and was crystallized from methanol to give 45.2 g methyl 2-(4-benzyloxyphenoxy)propanoate, m.p. 38°-42°.

المصدر