تفاعل #9286

معادلة التفاعل

nitronium tetrafluoroborate

7-bromo-2-ethyl-4-methoxypyrazolo[1,5-a]pyridine

water

→

title compound

المردود 47.9%

7-Bromo-2-ethyl-4-methoxy-3-nitropyrazolo[1,5-a]pyridine

المردود 47.9%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   استخلاصextraction
3. 3
   غسيلthe extract was washed with saturated aqueous sodium hydrogencarbonate and brine
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

الإجراء التجريبي

After adding nitronium tetrafluoroborate (176 mg) to a solution of 7-bromo-2-ethyl-4-methoxypyrazolo[1,5-a]pyridine (282 mg) in acetonitrile (20 mL) at 0° C., the mixture was stirred for 20 minutes. Upon completion of the reaction, water was added, extraction was performed with ethyl acetate, the extract was washed with saturated aqueous sodium hydrogencarbonate and brine and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography (20 g), and the title compound (159 mg) was obtained from the n-hexane:ethyl acetate (3:1) fraction as yellow crystals.

المصدر