تفاعل #92852

معادلة التفاعل

2-chloroquinoxaline

methyl 2-(4-hydroxyphenoxy)propanoate

sodium hydride

hydrogen

→

product

المردود 43.2%

Methyl 2-[4-(2-quinoxalinyloxy)phenoxy]propanoate

المردود 43.2%

المذيبات

dimethylformamide

dimethylformamide

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated solid was filtered
2. 2
   أخرىcrystallized from methanol

الإجراء التجريبي

In a nitrogen atmosphere, a solution of 5.9 g (0.03 mole) methyl 2-(4-hydroxyphenoxy)propanoate in 20 cc of dimethylformamide was added dropwise at about 15° C. to 1.5 g (0.03 mole) 57% sodium hydride in 20 cc dimethylformamide. When the evolution of hydrogen ceased, 4.9 g (0.03 mole) 2-chloroquinoxaline was added and the reaction mixture was heated at 130° C. for 4 hours. After standing overnight at room temperature, the reaction mixture was poured into about 100 cc of cold water. The precipitated solid was filtered and crystallized from methanol to give 4.2 g of product, m.p. 110°-115°.

المصدر