تفاعل #92792

معادلة التفاعل

tert-butyl (2-cyanonaphtho[2,1-d]thiazol-7-yl)carbamate

thioanisole

trifluoroacetic acid

→

product

المردود 94.8%

7-aminonaphtho[2,1-d]thiazole-2-carbonitrile

المردود 94.8%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction was concentrated under reduced pressure

الإجراء التجريبي

To a stirred solution of tert-butyl (2-cyanonaphtho[2,1-d]thiazol-7-yl)carbamate (72 mg, 0.22 mmol) and thioanisole (0.5 mL) in 2 mL of DCM in an ice bath, 2 mL of trifluoroacetic acid was added. After 1 h, the reaction was concentrated under reduced pressure, and the product (47 mg, 94%) was isolated by silica gel chromatography eluting with 0→75% EtOAc in heptanes. 1H NMR (CD2Cl2) d 8.01 (d, 1H); 7.90 (dt, 1H); 7.76 (d, 1H); 7.09-7.16 (m, 2H).

المصدر