تفاعل #927257

معادلة التفاعل

1,1,2-tribromo-2-(hexyloxymethyl)cyclopropane

methyllithium

→

1-hexyloxymethyl-cyclopropene

المردود 71.5%

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was quenched with saturated ammonium chloride
2. 2
   غسيلThe reaction mixture was washed with water and brine
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   ترشيحfiltered

الإجراء التجريبي

A solution of 1.15 g of 1,1,2-tribromo-2-(hexyloxymethyl)cyclopropane (2.9 mmol) in 6 ml of ether was treated at −78° C. with 1.4 ml of methyllithium (1.4 M, 8.8 mmol). After 5 minutes, the reaction mixture was warmed to 0° C. and held at this temperature. The reaction was quenched with saturated ammonium chloride. The reaction mixture was washed with water and brine, dried over magnesium sulfate, filtered and stripped to give 320 mg of 1-hexyloxymethyl-cyclopropene, as a dark yellow liquid.

المصدر