تفاعل #927236

معادلة التفاعل

7-octynyl-p-toluenesulfonate

sodium iodide

→

8-iodo-1-octyne

المردود 94.2%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىto react for four hours
2. 2
   درجة الحرارةunder reflux
3. 3
   درجة الحرارةAfter cooling
4. 4
   أخرىthe precipitates were removed by filtration
5. 5
   تركيزthe filtrate was concentrated
6. 6
   أخرىThe resulting residue was purified by silica gel column chromatography (eluent; hexane)

الإجراء التجريبي

A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).

المصدر