تفاعل #92712

معادلة التفاعل

tert-butyl[(1R,2R)-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate

N-bromosuccinimide

2,2′-azodiisobutyronitrile

→

tert-butyl[(1R,2S)-3-bromo-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate

المردود 29.0%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added portionwise
2. 2
   ترشيحThe insoluble material was filtered
3. 3
   workup.ADDITIONan aqueous sodium thiosulfate solution and chloroform were added
4. 4
   أخرىa layer separation operation
5. 5
   تجفيفAfter drying over anhydrous sodium sulfate
6. 6
   أخرىthe solvent was evaporated under reduced pressure
7. 7
   أخرىThe obtained residue was purified by silica gel column chromatography

الإجراء التجريبي

A solution of 2.75 g of tert-butyl[(1R,2R)-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate in 55 ml of carbon tetrachloride was heated at an outer temperature of 100° C., and a mixture of 1.53 g of N-bromosuccinimide and 95 mg of 2,2′-azodiisobutyronitrile was added portionwise thereto over 30 minutes at an interval of 5 minutes, followed by stirring at an outer temperature of 100° C. for 1 hour. The insoluble material was filtered, and an aqueous sodium thiosulfate solution and chloroform were added thereto to carry out a layer separation operation. After drying over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 984 mg of tert-butyl[(1R,2S)-3-bromo-2-(methoxymethoxy)-2,3-dihydro-1H-inden-1-yl](methoxymethyl)carbamate.

المصدر