تفاعل #92691

معادلة التفاعل

ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate

trifluoroacetic acid

→

ethyl 1-[(2R)-2-amino-2-phenylethyl]piperidine-4-carboxylate

المردود 102.2%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated under reduced pressure
2. 2
   workup.ADDITIONa saturated aqueous sodium carbonate solution and a chloroform-methanol mixed solution were added
3. 3
   أخرىa layer separation operation
4. 4
   تجفيفAfter drying over anhydrous magnesium sulfate
5. 5
   أخرىthe solvent was evaporated under reduced pressure

الإجراء التجريبي

To a solution of 160 mg of ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate in 1.5 mL of dichloromethane was added 0.7 mL of trifluoroacetic acid, followed by stirring for 1 hour. The solvent was evaporated under reduced pressure, and a saturated aqueous sodium carbonate solution and a chloroform-methanol mixed solution were added thereto in this order to carry out a layer separation operation. After drying over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure to obtain 120 mg of ethyl 1-[(2R)-2-amino-2-phenylethyl]piperidine-4-carboxylate.

المصدر