تفاعل #92678

معادلة التفاعل

diisopropyl ether

3-(cyclohexylmethoxy)-5-methylpyridin-2-amine

ethyl 2-chloro-3-oxobutanoate

triethylamine

→

ethyl 8-(cyclohexylmethoxy)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

المذيبات

water

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter leaving
2. 2
   درجة الحرارةto be cooled at room temperature
3. 3
   أخرىa layer separation operation
4. 4
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
5. 5
   أخرىthe solvent was evaporated under reduced pressure
6. 6
   أخرىThe obtained residue was purified by silica gel column chromatography

الإجراء التجريبي

To a solution of 1.38 g of 3-(cyclohexylmethoxy)-5-methylpyridin-2-amine in 24 ml of toluene were added 1.21 ml of ethyl 2-chloro-3-oxobutanoate and 1.23 ml of triethylamine, followed by stirring at 110° C. for 3 days. After leaving to be cooled at room temperature, water and diisopropyl ether were added thereto to carry out a layer separation operation. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 1.52 g of ethyl 8-(cyclohexylmethoxy)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate.

المصدر