تفاعل #926339

معادلة التفاعل

3-ethyl-6-(3,4-methylenedioxyphenyl)-3-hexenyl iodide

lithium

2,4-hexanedione

→

3-[3-Ethyl-6-(3,4-methylenedioxyphenyl)-3-hexenyl]-2,4-hexanedione

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىwas prepared from 23.2 g
2. 2
   أخرىof crude product which was chromatographed on 600 g
3. 3
   workup.ADDITIONof silica gel in pentane solution containing 20% benzene
4. 4
   غسيلThe column was eluted with the pentane-benzene-ether solvent series

الإجراء التجريبي

[I; Ar is 3,4-methylenedioxyphenyl, R0 is H, R' is CH3CO, R" is CH3CH2CO, Y is C(C2H5)=CHCH2CH2 ] was prepared from 23.2 g. of 3-ethyl-6-(3,4-methylenedioxyphenyl)-3-hexenyl iodide (Preparation D1) and 22.3 g. of the lithium salt of 2,4-hexanedione (prepared by the procedure described in Example 8 below) in 300 ml. of dimethylformamide according to the procedure described above in Example 2. There was thus obtained 21 g. of crude product which was chromatographed on 600 g. of silica gel in pentane solution containing 20% benzene. The column was eluted with the pentane-benzene-ether solvent series. Benzene containing 3% ether brought out the desired product, 14.5 g. of 3-[3-ethyl-6-(3,4-methylenedioxyphenyl)-3-hexenyl]-2,4-hexanedione as a yellow oil.

المصدر