تفاعل #92633

معادلة التفاعل

1′-benzyl-2-oxo-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carbonitrile

water

→

crude product

المردود 58.0%

1′-Benzyl-2-oxo-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide

المردود 58.0%

المذيبات

H3PO4

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with EA (10 mL×3)
2. 2
   تجفيفThe combined organic layers were dried over Na2SO4
3. 3
   تركيزconcentrated

الإجراء التجريبي

A solution of 1′-benzyl-2-oxo-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carbonitrile (200 mg, 0.42 mmol) in H3PO4 (15 mL) was heated to 120° C. for 2 hr. The solution was poured to water (10 mL) and extracted with EA (10 mL×3). The combined organic layers were dried over Na2SO4 and concentrated to give the crude product (120 mg, 58.0%) as an off-white solid. MS (ESI, m/e) [M+1]+ 493.9.

المصدر