تفاعل #92586

معادلة التفاعل

1′-benzyl-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide

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crude product

المردود 51.4%

6-(4-Phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide

المردود 51.4%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtrated
2. 2
   تركيزthe filtrate was concentrated

الإجراء التجريبي

A mixture of 1′-benzyl-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide (50 mg, 0.10 mmol), 10% w/w Pd(OH)2/C (5 mg) in MeOH (10 mL) and HOAc (1 drop) was stirred for 16 hr under H2. The mixture was filtrated and the filtrate was concentrated to give the crude product (20 mg 51.4%) as a yellow solid. MS (ESI, m/e) [M+1]+ 390.0.

المصدر