تفاعل #92407

معادلة التفاعل

sodium carbonate

N-(3-bromo-5-nitrophenyl)acetamide

N2

2-(Benzofuran-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

→

N-(3-(benzofuran-2-yl)-5-nitrophenyl)acetamide

المذيبات

1,2-dimethoxyethane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was degassed for another 5 min

الإجراء التجريبي

A solution of N-(3-bromo-5-nitrophenyl)acetamide of Example 1(c) (2 g, 7.7 mmol) in 1,2-dimethoxyethane (25 ml) was degassed by N2 bubbling for 5 min. 2-(Benzofuran-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2.45 g, 10 mmol, 1.3 eq.) was added and the mixture was degassed for another 5 min. Pd(dppf)Cl2 (0.63 g, 0.77 mmol, 0.1 eq.) and aqueous sodium carbonate (2.45 g, 23.1 mmol, 3.0 eq.) were added and the procedure of Example 1(d) was followed. The crude residue of the product was directly used for the next step.

المصدر