تفاعل #92359

معادلة التفاعل

4-iodo-1H-pyrazole

K2CO3

bromocyclopentane

→

1-Cyclopentyl-4-iodo-1H-pyrazole

المردود 89.5%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was quenched
2. 2
   استخلاصextracted as in Intermediate Example 5(a)
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   أخرىto give the product in 89.5% yield
5. 5
   أخرى263 [M+H]+ (rt: 1.57 min)

الإجراء التجريبي

To a solution of 4-iodo-1H-pyrazole (5 g, 25.78 mmol, 1.0 eq.) in DMF (25 ml) were added K2CO3 (8.908 g, 64.45 mmol, 2.5 eq.) and bromocyclopentane (4.96 g, 33.51 mmol, 1.3 eq.). The mixture was stirred at RT for 12 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to give the product in 89.5% yield. 1H NMR (300 MHz, CDCl3): δ 7.49 (s, 1H), 7.45 (s, 1H), 4.66-4.62 (m, 1H), 2.17-2.02 (m, 1H), 2.00-1.96 (m, 2H), 1.93-1.78 (m, 2H), 1.73-1.67 (m, 2H). LC-MS (ESI): Calculated mass: 262; Observed mass: 263 [M+H]+ (rt: 1.57 min).

المصدر