تفاعل #9221

معادلة التفاعل

bromine

4-benzylaniline

KSCN

→

desired compound

المردود 88.2%

2-Amino-6-benzyl-benzothiazole

المردود 88.2%

المذيبات

acetic acid

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate was filtered off
2. 2
   غسيلwashed with Et2O
3. 3
   أخرىa new precipitate was formed
4. 4
   ترشيحIt was filtered off
5. 5
   غسيلwashed with water and MeOH
6. 6
   أخرىdried under vacuum

الإجراء التجريبي

A solution of 4-benzylaniline (0.916 g, 5.00 mmol) and KSCN (0.97 g, 10.0 mmol, 2.0 eq) in 10 mL acetic acid was cooled at about 5° C., and was treated dropwise with a solution of bromine (0.258 mL, 5.00 mmol, 1.0 eq) in 2 mL acetic acid. The mixture was stirred at room temperature for about 1 hour. The precipitate was filtered off and washed with Et2O. The obtained solid was neutralized with saturated sodium carbonate solution, and a new precipitate was formed. It was filtered off, washed with water and MeOH, and dried under vacuum to give the desired compound 1.06 g (88%). LC/MS 241.2 (M+1); LC retention time 2.46 min.

المصدر