تفاعل #9211

معادلة التفاعل

1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

1-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

potassium carbonate

2-(2-methoxyethoxy)ethyl bromide

→

desired compound 12

المردود 39.0%

1-(6-Bromo-7-(2-(2-methoxyethoxy)ethoxy)-2-benzothiazolyl)-3-ethyl-urea

المردود 39.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىwas reacted

الإجراء التجريبي

A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and 2-(2-methoxyethoxy)ethyl bromide in DMF was reacted to give 0.026 g (39%) of the desired compound 12. 1H NMR (DMSO) δ 10.65 (br s, 1H, NH), 7.54 (d, 1H, J=8.5 Hz, ArH), 7.32 (d, 1H, J=8.6 Hz, ArH), 6.73 (br s, 1H, NH), 4.24 (d, 2H, J=4.4 Hz, CH2), 3.76 (d, 2H, J=4.8 Hz, CH2), 3.61 (dd, 2H, J=6.0, 5.2 Hz, CH2), 3.48 (dd, 2H, J=6.0, 5.2 Hz, CH2), 3.26 (s, 3H CH3), 3.19 (m, 2H, CH2), 1.09 (t, 3H, J=7.1 Hz, CH3); LC/MS 418 (MH+); RP-HPLC RT 2.95 minutes.

المصدر