تفاعل #92063

معادلة التفاعل

water

pivaloyl chloride

compound 5

2-amino-4-trifluoromethyl-5-bromopyridine

triethylamine

→

solid

المردود 85.7%

N-(5-bromo-4-(trifluoromethyl)pyridin-2-yl) pivalamide

المردود 85.7%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred at room temperature for 10 minutes
2. 2
   أخرىThe organic layer was separated
3. 3
   تجفيفdried over anhydrous sodium sulfate
4. 4
   تركيزconcentrated
5. 5
   أخرىseparated through a short column with ethyl acetate

الإجراء التجريبي

In an ice bath, 29.8 g of pivaloyl chloride (226 mmol) was added dropwise to a solution of compound 5 (50.0 g, 207 mmol) and triethylamine (37.9 mL) in dichloromethane (300.0 mL) within one hour and then stirred for 2 hours until the starting materials disappeared. 150 mL of water was added into the reaction solution and stirred at room temperature for 10 minutes. The organic layer was separated, dried over anhydrous sodium sulfate, concentrated, and separated through a short column with ethyl acetate to give white solid (57.7 g, 85.6%).

المصدر