تفاعل #9191

معادلة التفاعل

ethyl-2-amino-thiazole-5-carboxylate

di-t-butyldicarbonate

tetrahydrofuran

→

title compound

المردود 70.0%

Ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate

المردود 70.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated in vacuo
2. 2
   غسيلThe solid was washed with ether (10 mL, 3×)
3. 3
   أخرىdried in vacuo

الإجراء التجريبي

A suspension of ethyl-2-amino-thiazole-5-carboxylate (972 mg, 6 mmol, B. Plouvler, C. Bailly, R. Houssin, j-P. Henlchart Heterocyles 32(4), 693–701, 1991 and H. J. Becker, J. de Jonge Rec. Trav. Chim, 61, 463, 1942), di-t-butyldicarbonate (1.94 g, 9 mmol) and 4-dimethylaminopyridine (73 mg, 0.6 mmol) in dry tetrahydrofuran (75 mL) was stirred under nitrogen for 24 h. The solvent was evaporated in vacuo. The residue was suspended in ether (50 mL). The solid was washed with ether (10 mL, 3×), and dried in vacuo to obtain the title compound (1.1 g, 70%).

المصدر