تفاعل #9190

معادلة التفاعل

HCl

Ethyl-2-[(methylsulfonyl)amino]-4-methyl-thiazole-5-carboxylate

NaOH

→

2-[(Methylsulfonyl)amino]-4-methyl-thiazole-5-carboxylic acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was cooled to 0° C.
2. 2
   استخلاصThe solution was extracted with dichloromethane-chloroform mixture
3. 3
   استخلاصThe organic extract
4. 4
   تجفيفwas dried (MgSO4)
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated in vacuo
7. 7
   أخرىto obtain the title acid (148 mg, 55%)

الإجراء التجريبي

A stirred solution of Ethyl-2-[(methylsulfonyl)amino]-4-methyl-thiazole-5-carboxylate (300 mg, 1.14 mmol) in methanol (9 mL) was treated with a 1N NaOH solution (28.4 mL, 28.4 mmol). The mixture was stirred at rt overnight. The solution was cooled to 0° C. and acidified with 6N aq. HCl solution to pH 1. The solution was extracted with dichloromethane-chloroform mixture. The organic extract was dried (MgSO4), filtered and concentrated in vacuo to obtain the title acid (148 mg, 55%).

المصدر