تفاعل #9184

معادلة التفاعل

HCl

ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate

KOH

→

2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylic acid

المذيبات

tetrahydrofuran-ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was cooled to 0° C.
2. 2
   أخرىThe solvent was evaporated in vacuo
3. 3
   غسيلThe residue was washed with water, diethyl ether
4. 4
   تجفيفdried in vacuo over anhydrous phosphorous pentoxide
5. 5
   أخرىto obtain the title acid (6 g, 89%) as a white solid

الإجراء التجريبي

A stirred solution of ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate (10 g, 34.95 mmol) in tetrahydrofuran-ethanol (250 mL, 2:3) was treated with a 6N KOH solution (250 mL). The mixture was heated to 55° C. overnight. The solution was cooled to 0° C. and acidified with concd. HCl to pH 1. The solvent was evaporated in vacuo. The residue was washed with water, diethyl ether, dried in vacuo over anhydrous phosphorous pentoxide to obtain the title acid (6 g, 89%) as a white solid.

المصدر