تفاعل #918

معادلة التفاعل

N-(1,1-dimethylethyl)-2-[(methoxyimino)-methyl]-1H-pyrrole-3-sulfonamide

TFA

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title compound

2-[(Methoxyimino)methyl]-1-methyl-1H-pyrrole-3-sulfonamide

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   تركيزThe orange reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONThree portions of diethyl ether were added to the residue
3. 3
   أخرىremoved by evaporation
4. 4
   أخرىto remove residual TFA

الإجراء التجريبي

To a solution of 5.74 g (21.9 mmol) of N-(1,1-dimethylethyl)-2-[(methoxyimino)-methyl]-1H-pyrrole-3-sulfonamide in 75 mL methylene chloride under a nitrogen atmosphere was add 75 mL of TFA. The clear orange reaction mixture was allowed to stir at room temperature overnight ca. 16 hours. The orange reaction mixture was concentrated in vacuo. Three portions of diethyl ether were added to the residue and removed by evaporation to remove residual TFA, affording 3.49 g of the title compound as a gray solid, m.p. 120°-122° C.

المصدر