تفاعل #91662

معادلة التفاعل

sodium carbonate

3-Bromophenol

pyridin-3-ylboronic acid

→

3-(pyridin-3-yl)phenol

المردود 78.8%

المذيبات

dimethoxyethane water

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the completion of the reaction
2. 2
   ترشيحthe reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   تجفيفThe obtained organic layer was dried over magnesium sulfate
6. 6
   أخرىpurified by column chromatography (hexane:ethyl acetate=9:1)

الإجراء التجريبي

3-Bromophenol (500 mg, 2.86 mmol) and pyridin-3-ylboronic acid (422 mg, 3.76 mmol) were dissolved in dimethoxyethane/water=5 mL/2.5 mL. Pd(dppf)Cl2 (118 mg, 0.14 mmol) and sodium carbonate (919 mg, 8.67 mmol) were added thereto, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 3-(pyridin-3-yl)phenol (386 mg, 78%).

المصدر