تفاعل #91389

معادلة التفاعل

N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine hydrochloride

{[5-(trifluoromethyl)pyridin-2-yl]methyl}amine

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titled compound

N4-cyclohexyl-5,6-dimethyl-N2-{[5-(trifluoromethyl)pyridin-2-yl]methyl}pyrimidine-2,4-diamine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe titled compound was synthesized
2. 2
   أخرىThe product was purified by column chromatography
3. 3
   غسيلeluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. 4
   غسيلthe final product was washed with diethyl ether

الإجراء التجريبي

The titled compound was synthesized according to the general procedure described for preparation of N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 1) using {[5-(trifluoromethyl)pyridin-2-yl]methyl}amine instead of (pyridin-2-ylmethyl)amine. The product was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a light-grey solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.04-1.16 (m, 3H), 1.16-1.19 (m, 2H), 1.38 (d, J=10.21 Hz, 2H), 1.55 (s, 3H), 1.86 (s, 3H), 2.26 (bs, 3H) 3.53 (d, J=5.37 Hz, 1H), 4.73 (s, 2H), 7.53 (d, J=7.52 Hz, 2H), 8.15 (d, J=7.79 Hz, 2H), 8.89 (s, 1H), 12.98 (bs, 1H); MS (ESI) m/z 380.0 (M+1)+.

المصدر