تفاعل #91388

معادلة التفاعل

N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine hydrochloride

[(6-methylpyridin-2-yl)methyl]amine

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titled compound

N4-cyclohexyl-5,6-dimethyl-N2-[(6-methylpyridin-2-yl)methyl]pyrimidine-2,4-diamine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe titled compound was synthesized
2. 2
   أخرىThe product was purified by column chromatography
3. 3
   غسيلeluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. 4
   غسيلthe final product was washed with diethyl ether

الإجراء التجريبي

The titled compound was synthesized according to the general procedure described for preparation of N4-cyclohexyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 1) using [(6-methylpyridin-2-yl)methyl]amine instead of (pyridin-2-ylmethyl)amine. The product was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a light-grey solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.13-1.18 (m, 5H), 1.56-1.59 (m, 5H), 1.87 (s, 3H), 2.21 (s, 3H), 2.49 (s, 3H), 3.63 (d, J=6.72 Hz, 1H), 4.62 (d, J=4.30 Hz, 2H), 7.21-7.23 (m, 2H), 7.56 (d, J=5.64 Hz, 1H), 7.76-7.80 (m, 1H), 8.24 (s, 1H), 12.39 (s, 1H); MS (ESI) m/z 326.5 (M+1)+.

المصدر