تفاعل #91368

معادلة التفاعل

6-methoxy-1-tetralone

Selectfluor

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title compound

المردود 42.1%

5-fluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-one

المردود 42.1%

المذيبات

ACN

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction was filtered
2. 2
   تركيزconcentrated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in EtOAc (40 mL)
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated
6. 6
   أخرىPurification by silica gel chromatography (PE/EtOAc/DCM=20:1:2)

الإجراء التجريبي

To a solution of 6-methoxy-1-tetralone (200 mg, 1.1 mmol) in ACN (20 mL) was added Selectfluor (603 mg, 1.7 mmol) at rt, and the reaction was stirred at 40° C. overnight. The reaction was filtered and concentrated. The residue was dissolved in EtOAc (40 mL), filtered, and concentrated. Purification by silica gel chromatography (PE/EtOAc/DCM=20:1:2) gave 90 mg (41%) of the title compound as a yellow solid. [M+H] Calc'd for C11H11FO2, 195. Found, 195.

المصدر