تفاعل #91303

معادلة التفاعل

2,4-diaminophenol.2HCl

naphthalene-1-carboxylic acid

NaOH

→

2-(naphthalene-1-yl)benzo[d]oxazole-5-amine

المردود 77.0%

المذيبات

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   درجة الحرارةthe reaction solution was cooled
3. 3
   ترشيحfiltered
4. 4
   workup.DISTILLATIONby using distilled water
5. 5
   أخرىfor recrystallization in a slow manner

الإجراء التجريبي

8 mmol of 2,4-diaminophenol.2HCl and 8 mmol of naphthalene-1-carboxylic acid were dissolved in 10 g of polyphosphoric acid (PPA), and then, the mixed solution was stirred at a temperature of 180° C. for 3 to 4 hours. After completion of the reaction, the reaction solution was cooled, neutralized with 10% NaOH, and filtered by using distilled water for recrystallization in a slow manner, thereby obtaining 1.6 g of 2-(naphthalene-1-yl)benzo[d]oxazole-5-amine (Derivative #2) (yield: 77%).

المصدر