تفاعل #91262

معادلة التفاعل

3-Chloromethyl-2-cyclobutylsulfanyl-pyridine

2-(4-hydroxy-2,3-dimethyl-phenyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

المردود 82.3%

2-[4-(2-cyclobutylsulfanyl-pyridin-3-ylmethoxy)-2,3-dimethyl-phenyl]-cyclopropane carboxylic acid

المردود 82.3%

ظروف التفاعل

المعالجة

1. 1
   أخرىto react sequentially in the same manner as in Steps A and B of Example 1

الإجراء التجريبي

3-Chloromethyl-2-cyclobutylsulfanyl-pyridine (0.032 g, 0.149 mmol) obtained in Step C of Preparation Example 23 and 2-(4-hydroxy-2,3-dimethyl-phenyl)-cyclopropane carboxylic acid ethyl ester (0.035 g, 0.149 mmol) obtained in Step C of Preparation Example 48 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.047 g, 82%).

المصدر