تفاعل #91250

معادلة التفاعل

3-Chloromethyl-2-isopropylsulfanyl-pyridine

2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

المردود 80.0%

2-[3-chloro-4-(2-isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

المردود 80.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىto react sequentially in the same manner as in Steps A and B of Example 1

الإجراء التجريبي

3-Chloromethyl-2-isopropylsulfanyl-pyridine (33 mg, 0.16 mmol) obtained in Step C of Preparation Example 1 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (43 mg, 0.17 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (42 mg, 80%).

المصدر