تفاعل #91195

معادلة التفاعل

2-Fluoro-4-methoxy-benzaldehyde

carbethoxy methylene triphenylphosphorane

→

title compound

المردود 83.0%

(E)-3-(2-fluoro-4-methoxy-phenyl)-acrylic acid ethyl ester

المردود 83.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the termination of the reaction
2. 2
   درجة الحرارةthe reactant was cooled
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىpurified by column chromatography (eluent, EtOAc/Hex=1/10)

الإجراء التجريبي

2-Fluoro-4-methoxy-benzaldehyde (1.24 g, 3.56 mmol) and carbethoxy methylene triphenylphosphorane (2.0 g, 5.78 mmol) were dissolved in THF (10 mL), and the mixture was stirred at 65˜75° C. for 1 hour. After the termination of the reaction, the reactant was cooled, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/10) to obtain the title compound (0.6 g, 83%).

المصدر