تفاعل #91184

معادلة التفاعل

2-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropanecarboxylic acid methyl ester

2-(4-benzyloxy-3,5-difluoro-phenyl)-cyclopropane carboxylic acid methyl ester

→

title compound

المردود 112.9%

2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropane carboxylic acid methyl ester

المردود 112.9%

المذيبات

THF MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

2-(4-Benzyloxy-3,5-difluoro-phenyl)-cyclopropanecarboxylic acid methyl ester (21 mg, 0.066 mmol) obtained in Step B was dissolved in THF/MeOH (1 mL/1 mL), and Pd/C (10%, 10 mg) was added thereto. The mixture was stirred under hydroten atmosphere for 12 hours, filtered by using celite, and concentrated under reduced pressure to obtain the title compound (17 mg, 99%).

المصدر