تفاعل #91036

معادلة التفاعل

DIPEA

3,4-dichloro-5-isopropoxybenzoic acid

3,4-Dichloro-5-isopropoxybenzoic acid

methyl 4-amino-2-methylbenzoate

→

Methyl 4-(3,4-dichloro-5-isopropoxybenzamido)-2-methylbenzoate

المردود 68.0%

ظروف التفاعل

الإجراء التجريبي

Methyl 4-(3,4-dichloro-5-isopropoxybenzamido)-2-methylbenzoate (10) (237 mg, 68%) was prepared from 3,4-dichloro-5-isopropoxybenzoic acid (8) (200 mg, 800 μmol) using a procedure essentially the same as in step (i) for AAA-064 except that DIPEA was used instead of TEA, and methyl 4-amino-2-methylbenzoate (9) was used instead of methyl 4-amino-2-fluorobenzoate: m/z 396 [M+H]+ (ES+), 394 [M−H]− (ES−), 1H NMR (400 MHz, DMSO-d6) δ: 10.51 (1H, s), 7.89 (1H, d), 7.81 (1H, d), 7.77-7.72 (2H, m), 7.64 (1H, d), 4.85 (1H, sep), 3.81 (3H, s), 2.54 (3H, s), 1.35 (6H, d).

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