تفاعل #91026

معادلة التفاعل

methyl 4-(3-chloro-5-isopropoxy-4-methoxybenzamido)-2-methylbenzoate

Methyl 4-(3-chloro-5-isopropoxy-4-methoxybenzamido)-2-methylbenzoate

→

4-(3-Chloro-5-isopropoxy-4-methoxybenzamido)-2-methylbenzoic acid

المردود 57.0%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise until a solution
2. 2
   أخرىformed

الإجراء التجريبي

4-(3-Chloro-5-isopropoxy-4-methoxybenzamido)-2-methylbenzoic acid (AAA-075) (94 mg, 57%) was prepared from methyl 4-(3-chloro-5-isopropoxy-4-methoxybenzamido)-2-methylbenzoate (7) (167 mg, 4.10 mmol) using a procedure essentially the same as in step (ii) for AAA-001 except that MeOH was added dropwise until a solution formed and the mixture was stirred at 40° C. for 18 h: m/z 378 [M+H]+ (ES+), 376 [M−H]− (ES−). 1H NMR (400 MHz, DMSO-d6) δ:12.63 (1H, br s), 10.34 (1H, s), 7.86 (1H, d), 7.75-7.63 (3H, m), 7.57 (1H, d), 4.77 (1H, sep), 3.83 (3H, s), 2.53 (3H, s), 1.34 (6H, d).

المصدر