تفاعل #90806

معادلة التفاعل

5-fluoro-N-methyl-2-nitrobenzamide

1-(2-hydroxyethyl)piperazine

Hunig's base

→

5-[4-(2-Hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe residue was purified by flash column

الإجراء التجريبي

A solution of 5-fluoro-N-methyl-2-nitrobenzamide, 1-(2-hydroxyethyl)piperazine, and Hunig's base in 20 mL of DMF was stirred at room temperature over the weekend. The resulting mixture was rotavaped to dryness, and the residue was purified by flash column SF40-150 at 2%-10% MeOH/CH2Cl2. Product came out at 7% MeOH/CH2Cl2. MS(ES) m/e 309 [M+H].

المصدر