تفاعل #9064

معادلة التفاعل

4-(Benzimidazol-2-yl)-benzyl alcohol

→

4-(benzimidazol-2-yl)-benzaldehyde

المردود 42.0%

المذيبات

CH2Cl2

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered through celite
2. 2
   غسيلthe cake washed with CH2Cl2
3. 3
   أخرىthe solvent from the eluent removed under reduced pressure

الإجراء التجريبي

4-(Benzimidazol-2-yl)-benzyl alcohol from above (0.175 g, 0.78 mmol) was dissolved in CH2Cl2 (5 mL) and THF (8 mL), treated with activated MnO2 (0.68 g, 7.8 mmol) and stirred at room temperature for 1.5 h. The mixture was filtered through celite, the cake washed with CH2Cl2 and the solvent from the eluent removed under reduced pressure to afford 4-(benzimidazol-2-yl)-benzaldehyde (92 mg, 42%). 1H NMR (CD4OD) δ 7.28 (m, 2H), 7.60 (br, 1H (NH)), 7.65 (d, 2H, J=7.8 Hz), 8.09 (d, 2H, J=7.8 Hz), 8.30 (d, 2H, J=9.0 Hz), 10.08 (s, 1H (CHO)).

المصدر