تفاعل #90550

معادلة التفاعل

PTSA

6-methoxy-5-morpholino-2, 3-dihydro-1H-inden-1-one

6-methoxy-5-morpholino-2,3-dihydro-1H-inden-1-one

2-chloro-5-(trifluoromethyl)benzaldehyde

→

crude compound 157

(E)-2-(2-chloro-5-(trifluoromethyl)benzylidene)-6-methoxy-5-morpholino-2, 3-dihydro-1H-inden-1-one

المذيبات

ethyl acetate

toluene

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water (3×25 mL)
2. 2
   تجفيفThe organic layer was dried over sodium sulphate
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a solution of 6-methoxy-5-morpholino-2, 3-dihydro-1H-inden-1-one 13 (0.120 mg, 0.485 mmol) in toluene (10 mL) was added 2-chloro-5-(trifluoromethyl)benzaldehyde 75 (0.101 mg, 0.485 mmol). PTSA (0.184 mg, 0.971 mmol) was added to the reaction mass, reaction stirred at 100° C. for 6 h, diluted with ethyl acetate and washed with water (3×25 mL). The organic layer was dried over sodium sulphate and concentrated to get the crude compound 157 which was purified through flash chromatography by using 100-200 mesh silica gel. The compound was eluted at 15% ethyl acetate in hexane to afford yellow coloured solid (E)-2-(2-chloro-5-(trifluoromethyl)benzylidene)-6-methoxy-5-morpholino-2, 3-dihydro-1H-inden-1-one 157.

المصدر