تفاعل #90526

معادلة التفاعل

PTSA

13

6-methoxy-5-morpholino-2,3-dihydro-1H-inden-1-one

4-((trifluoromethyl)thio)benzaldehyde

→

crude compound 73

(E)-6-methoxy-5-morpholino-2-(4-((trifluoromethyl)thio)benzylidene)-2,3-dihydro-1H-inden-1-one

المذيبات

ethyl acetate

toluene

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water (3×25 mL)
2. 2
   تجفيفThe organic layer was dried over sodium sulphate
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a solution of 13 (1.2 g, 4.858 mmol) in toluene 40 mL was added 4-((trifluoromethyl)thio)benzaldehyde 72 (1 g, 4.858 mmol). PTSA (1.84 g, 9.716 mmol) was added and the reaction mixture was stirred at 120° C. for 6 h. The reaction mass was diluted with ethyl acetate and washed with water (3×25 mL). The organic layer was dried over sodium sulphate and concentrated to get the crude compound 73, which was purified through flash chromatography by using 100-200 mesh silica gel. The compound (E)-6-methoxy-5-morpholino-2-(4-((trifluoromethyl)thio)benzylidene)-2,3-dihydro-1H-inden-1-one 73 was eluted at 37% ethyl acetate in hexane to afford yellow coloured solid.

المصدر