تفاعل #90523

معادلة التفاعل

PTSA

13

6-methoxy-5-morpholino-2,3-dihydro-1H-inden-1-one

3-(trifluoromethyl) picolinaldehyde

→

(E)-6-methoxy-5-morpholino-2-((3-(trifluoromethyl)pyridin-2-yl)methylene)-2,3-dihydro-1H-inden-1-one

المذيبات

ethyl acetate

toluene

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water (3×25 mL)
2. 2
   تجفيفThe organic layer was dried over sodium sulphate
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a solution of 13 (250 mg, 1.010 mmol) in toluene 10 mL was added 3-(trifluoromethyl) picolinaldehyde (177.0 mg, 1.010 mmol). PTSA (384.5 mg, 2.021 mmol) was added to the reaction mixture and stirred at 120° C. for 6 h. The reaction mass was diluted with ethyl acetate and washed with water (3×25 mL). The organic layer was dried over sodium sulphate and concentrated to get the crude compound (E)-6-methoxy-5-morpholino-2-((3-(trifluoromethyl)pyridin-2-yl)methylene)-2,3-dihydro-1H-inden-1-one 67. The compound 67 was purified through flash chromatography by using 100-200 mesh silica gel. The compound was eluted at 34% ethyl acetate in hexane to afford yellow coloured solid.

المصدر