تفاعل #90473

معادلة التفاعل

NaH

3,6-dibromocarbazole

N-(2-(oxiran-2-yl)ethyl)aniline

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colorless oil

المردود 57.5%

1-(3,6-dibromo-9H-carbazol-9-yl)-4-(phenylamino)butan-2-ol

المردود 57.5%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe resulting mixture was stirred at 60° C. overnight
2. 2
   أخرىTHF was removed under vacuum
3. 3
   workup.DISSOLUTIONthe residue was dissolved in 10 mL EtOAc
4. 4
   غسيلwashed with water 2×5 mL
5. 5
   تجفيفThe organic layer was dried over anhydrous Na2SO4
6. 6
   أخرىevaporated
7. 7
   أخرىto afford the crude product, which

الإجراء التجريبي

NaH (60% dispersed in mineral oil, 0.0018 g, 0.0452 mmol) was added to a solution of 3,6-dibromocarbazole (0.0147 g, 0.0452 mmol) in 0.5 mL anhydrous THF and the mixture was stirred for 15 min. N-(2-(oxiran-2-yl)ethyl)aniline (0.0067 g, 0.0410 mmol) in 1.5 mL anhydrous THF solution was added dropwise and the resulting mixture was stirred at 60° C. overnight. THF was removed under vacuum and the residue was dissolved in 10 mL EtOAc and washed with water 2×5 mL. The organic layer was dried over anhydrous Na2SO4 and evaporated to afford the crude product, which was subjected to silica gel chromatography using Hexanes/EtOAc to afford 0.0115 g colorless oil; yield 57.5%.

المصدر