تفاعل #90435

معادلة التفاعل

mCPBA

N-(but-3-enyl)-2-nitro-N-phenylbenzenesulfonamide

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colorless oil

المردود 97.0%

2-nitro-N-(2-(oxiran-2-yl)ethyl)-N-phenylbenzenesulfonamide

المردود 97.0%

المذيبات

water

NaHCO3

water

CHCl3

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةgradually warmed up to room temperature
2. 2
   workup.STIRRINGto stir for 18 hr
3. 3
   تجفيفThe organic layer was dried over anhydrous Na2SO4
4. 4
   أخرىevaporated
5. 5
   أخرىto afford the crude product, which

الإجراء التجريبي

mCPBA (77%, 0.0550 g, 0.246 mmol) was added to N-(but-3-enyl)-2-nitro-N-phenylbenzenesulfonamide (0.0653 g, 0.196 mmol) in 1 mL CHCl3 at 0° C. The mixture was stirred at 0° C. for 30 min, then gradually warmed up to room temperature and continued to stir for 18 hr. After TLC showed the disappearance of starting material, the reaction mixture was diluted with a 1:1 mixture of water and saturated NaHCO3 (2×10 mL) and water (10 mL). The organic layer was dried over anhydrous Na2SO4 and evaporated to afford the crude product, which was subjected to silica gel chromatography using Hexanes/EtOAc to afford 0.0662 g colorless oil as product, yield 96.9%.

المصدر