تفاعل #90394

معادلة التفاعل

VII

(E)-N′-(2,7-dicyanobenzo[d]thiazol-6-yl)-N,N-dimethylformimidamide

5-amino-2-methoxyphenol

KBr

→

9-(3-Hydroxy-4-methoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

المردود 54.0%

المذيبات

EtOAc

ظروف التفاعل

الإجراء التجريبي

Prepared from VII and 5-amino-2-methoxyphenol. Flash chromatography eluent (EtOAc). Yield: 54%; yellow solid; mp 248° C.; IR (KBr) νmax/cm−1 2921, 2851, 2227, 1724, 1647, 1616, 1583, 1509, 1460, 1334, 1287, 1263, 1218, 1172, 1148, 1120, 1036, 973, 953, 864, 833; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H, J=8.7 Hz), 8.05 (m, 1H), 7.77 (d, 1H, J=8.7 Hz), 7.94 (d, 2H, J=8.7 Hz), 6.65 (m, 1H), 3.77 (s, 3H); HRMS calcd for C17H12N5O2S (M+H+): 350.0712, found 350.0715.

المصدر