تفاعل #9029

معادلة التفاعل

2,2,2-trifluoro-1-piperazin-1-yl-ethanone

allyl bromide

potassium carbonate

→

piperazine

المردود 155.1%

1-allyl-piperazine

المردود 155.1%

المذيبات

CH3CN

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with CH2Cl2 (30 mL) and water (30 mL)
3. 3
   استخلاصthe aqueous layer extracted with CH2Cl2 (2×20 mL)
4. 4
   تجفيفThe combined organic extracts were dried (Na2SO4)
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a stirred solution of 2,2,2-trifluoro-1-piperazin-1-yl-ethanone (515 mg, 2.83 mmol) in dry CH3CN (6 mL) was added allyl bromide (0.32 mL, 3.7 mmol) and powdered potassium carbonate (0.78 g, 5.65 mmol) and the mixture stirred overnight. The reaction was concentrated under reduced pressure, diluted with CH2Cl2 (30 mL) and water (30 mL) and the aqueous layer extracted with CH2Cl2 (2×20 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated in vacuo to afford the crude di-protected piperazine (0.554 g) which was used without further purification in the next reaction.

المصدر