تفاعل #90085

معادلة التفاعل

hydrochloric acid

(3-bromo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-9-yl oxy)-acetic acid methyl ester

hydroxy-acetic acid methyl ester

sodium hydroxide

→

title compound

المردود 48.0%

(3-Bromo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-9-yl oxy)-acetic acid

المردود 48.0%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with diethyl ether
2. 2
   تجفيفdried over anhydrous magnesium sulfate
3. 3
   تركيزAfter the concentration under reduced pressure
4. 4
   أخرىwhite solid was obtained
5. 5
   غسيلwhich was then washed with methylene chloride

الإجراء التجريبي

Under the same conditions as the method for synthesizing Compound A7-1, (3-bromo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-9-yl oxy)-acetic acid methyl ester was prepared from Compound JJ2 and hydroxy-acetic acid methyl ester. The resultant was dissolved in MeOH (0.35 ml), added with aqueous solution of sodium hydroxide (6 mol/1), and stirred at room temperature for 10 min. The reaction solution was added with hydrochloric acid (3 mol/1), extracted with diethyl ether and dried over anhydrous magnesium sulfate. After the concentration under reduced pressure, white solid was obtained, which was then washed with methylene chloride to obtain the title compound (11.2 mg, 48%).

المصدر