تفاعل #90083

معادلة التفاعل

3-Bromo-9-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one

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title compound

المردود 98.1%

3-Bromo-9-((R)-2,3-dihydroxy-propoxy)-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one

المردود 98.1%

المذيبات

methanol

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   تركيزthe reaction solution was concentrated under reduced pressure
3. 3
   workup.ADDITIONthe resulting residues were added with dichloromethane
4. 4
   أخرىthe solid was separated by filtration

الإجراء التجريبي

3-Bromo-9-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one (Compound JJ3-1, 18.7 mg, 0.0398 mmol) was dissolved in methanol (1 mL) and THF (0.3 mL), added with 1 N hydrochloric acid (5 drops) and stirred at 50° C. for 1 hr. After cooling, the reaction solution was concentrated under reduced pressure, and the resulting residues were added with dichloromethane, and the solid was separated by filtration to obtain the title compound (yellow powder, 16.8 mg, 98%).

المصدر