تفاعل #89764

معادلة التفاعل

methyl(3R,4S)-1-[(Z)-(cyanoimino)(phenoxy)methyl]-4-[4-(4-cyano-2-methylphenyl)piperazin-1-yl]carbonylpiperidine-3-carboxylate

acetonitrile

piperidine

→

methyl(3R,4S)-1-[(E)-(cyanoimino)(piperidin-1-yl)methyl]-4-[4-(4-cyano-2-methylphenyl)piperazin-1-yl]carbonylpiperidine-3-carboxylate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture refluxed (oil bath at 85 deg)
2. 2
   أخرىUpon completion reaction mixture
3. 3
   تركيزconcentrated in vacuum
4. 4
   أخرىThe residue was purified by combiflash
5. 5
   أخرىto give
6. 6
   أخرىthe product (53.3 mg, 98% in yield)

الإجراء التجريبي

To a stirred solution of methyl(3R,4S)-1-[(Z)-(cyanoimino)(phenoxy)methyl]-4-[4-(4-cyano-2-methylphenyl)piperazin-1-yl]carbonylpiperidine-3-carboxylate (52 mg, 0.00010 mol) in acetonitrile (2.006 mL, 0.03840 mol) was added piperidine (0.200 mL, 0.00202 mol). The reaction mixture refluxed (oil bath at 85 deg). Upon completion reaction mixture concentrated in vacuum. The residue was purified by combiflash using 0-5% methanol/dichloromethane to give the product (53.3 mg, 98% in yield). MS (ESI): (M+H)+=506.

المصدر