تفاعل #89756

معادلة التفاعل

methyl chloroformate

methyl(2S,3S,5S)-5-tert-butoxy-2-[(4-phenylpiperazin-1-yl)carbonyl]piperidine-3-carboxylate

methylene chloride

→

dimethyl(2S,3S,5S)-5-tert-butoxy-2-[(4-phenylpiperazin-1-yl)carbonyl]piperidine-1,3-dicarboxylate

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter quenched with aq. sodium bicaronate
2. 2
   استخلاصthe reaction was extracted with ethyl acetate
3. 3
   غسيلThe combined organic layers were washed with brine
4. 4
   أخرىdried
5. 5
   تركيزconcentrated
6. 6
   أخرىto dry

الإجراء التجريبي

To a mixture of methyl(2S,3S,5S)-5-tert-butoxy-2-[(4-phenylpiperazin-1-yl)carbonyl]piperidine-3-carboxylate (0.03345 g, 8.290E-5 mol) and 4-dimethylaminopyridine (0.0152 g, 0.000124 mol) in methylene chloride (1.50 mL, 0.0234 mol) was added methyl chloroformate (0.00833 mL, 0.000108 mol). The reaction was stirred at rt overnight. After quenched with aq. sodium bicaronate, the reaction was extracted with ethyl acetate. The combined organic layers were washed with brine, dried, concentrated to dry. The resulting residue was used directly in next step. MS (ESI): (M+H)+=462.2.

المصدر