تفاعل #89551

معادلة التفاعل

4-Fluoro-7-methylindoline-2,3-dione

H2O2

→

desired product

2-Amino-6-fluoro-3-methylbenzoic acid

المذيبات

NaOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to rt
2. 2
   ترشيحfiltered
3. 3
   درجة الحرارةcooled to 4° C.
4. 4
   ترشيحfiltered
5. 5
   أخرىThe filter cake was dried under vacuum

الإجراء التجريبي

4-Fluoro-7-methylindoline-2,3-dione (6.20 g, 34.6 mmol) in 1M NaOH (114 mL) was treated dropwise with 30% aq. H2O2 (20 mL), heated to 50° C. for 30 min, cooled to rt and filtered. The filtrate was adjusted to pH 4 with conc. HCl, cooled to 4° C. and filtered. The filter cake was dried under vacuum to provide the desired product. 1H NMR (CDCl3, 400 MHz) δ 7.15 (m, 1H), 6.40 (m, 1H), 2.15 (s, 3H).

المصدر