تفاعل #895

معادلة التفاعل

sodium thiomethoxide

4,6-dichloro-2-(phenylmethoxy)pyrimidine

→

4-chloro-6-methylthio-2-(phenylmethoxy)pyrimidine

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىto react for 2 hours
2. 2
   أخرىthe reaction solution was partitioned between ethyl acetate and aqueous saturated sodium hydrogen carbonate
3. 3
   غسيلThe organic layer was washed with aqueous saturated sodium chloride
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   تركيزconcentrated
6. 6
   أخرىpurified on a silica gel column

الإجراء التجريبي

Aqueous sodium thiomethoxide (15%, 2.75 g, 0.0059×1.0 mol) was added dropwise in 4,6-dichloro-2-(phenylmethoxy)pyrimidine (Compound No. II-26) (1.5 g, 0.0059 mol) dissolved in THF at room temperature. After allowed to react for 2 hours, the reaction solution was partitioned between ethyl acetate and aqueous saturated sodium hydrogen carbonate. The organic layer was washed with aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and concentrated, then purified on a silica gel column to obtain 4-chloro-6-methylthio-2-(phenylmethoxy)pyrimidine (Compound No. II-15) as an intermediate.

المصدر