تفاعل #89304

معادلة التفاعل

O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

5-methyl-2-(6-methylpyridin-2-yl)benzoic acid

tert-butyl (((2S,3R)-3-methylpiperidin-2-yl)methyl)carbamate

DIPEA

→

title compound

tert-Butyl (((2S,3R)-3-methyl-1-(5-methyl-2-(6-methylpyridin-2-yl)benzoyl)piperidin-2-yl)methyl)carbamate

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   غسيلwas washed with satd
2. 2
   تجفيفaq. NaHCO3 and brine and dried over Na2SO4
3. 3
   أخرىThe solvent was removed in vacuo

الإجراء التجريبي

To the mixture of 5-methyl-2-(6-methylpyridin-2-yl)benzoic acid (0.229 g, 0.868 mmol), tert-butyl (((2S,3R)-3-methylpiperidin-2-yl)methyl)carbamate (0.24 g, 1.04 mmol) and DIPEA (0.3 mL, 1.738 mmol) in DCM (20 mL) was slowly added O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU; 0.278 g, 0.869 mmol). The mixture was stirred at rt for 1 h. The mixture was diluted with DCM and was washed with satd. aq. NaHCO3 and brine and dried over Na2SO4. The solvent was removed in vacuo to obtain the title compound which was used without further purification. ESI-MS (m/z): 438 [M+1]+.

المصدر