تفاعل #8929

معادلة التفاعل

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

piperdine

→

benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100 mL round bottom flask equipped with magnetic stir bar
2. 2
   تركيزthen concentrated in vacuo
3. 3
   غسيلThe organic phase was washed with brine
4. 4
   أخرىdried
5. 5
   تركيزconcentrated in vacuo

الإجراء التجريبي

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1 g benzyl 3-chlorosulfonyl-2(R)-methylpropionate from Example 3 in 25 mL CH2Cl2. The solution was cooled to 0° C. and 4 mL of piperdine was slowly added. The reaction was stirred 1 hour then concentrated in vacuo. The residue was partioned between ethyl acetate and water. The organic phase was washed with brine, dried, and concentrated in vacuo to give 1 g of benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate suitable for use without further purification.

المصدر